Since there are no reported metabolic defects associated with reactions catalyzed by any of the transaminases, like reactions of the tricarboxylic acid cycle, all are considered essential for life. Ces enzymes sont presentes dans plusieurs tissus foie, coeur, reins, muscles. Elevated transaminases that persist less than six months are termed acute in nature, and those values that persist for six months or more are termed chronic in nature. Tgp, a doua enzima hepatica din cadrul transaminazelor. The transaminase enzymes are important in the production of various amino acids, and measuring the concentrations of various transaminases in the blood is important in the diagnosing and tracking many diseases. Conduite a tenir devant une elevation des transaminases pas a. Xray crystallographic structures of the holo and apo form of chromobacterium violaceum. Les transaminases sont des enzymes presentes a linterieur des cellules, particulierement au niveau du foie et des muscles. Ii distribuition of tryptophan transaminase activity in plants. As duas principais aminotransferases sao a tgo transaminase glutamica oxalacetica e tgp transaminase glutamica piruvica.
Alt is primarily localized to the liver and is considered a more specific test for. What levels of serum transaminases suggest intrahepatic. Por lo general son mundialmente aceptados, valores. Markedly elevated serum transaminase levels clinical advisor. For example, the presence of elevated transaminases can be an indicator of liver and cardiac damage. Neste artigo nos restringimos as ast ou tgo e alt ou tgp porque elas sao as mais uteis e importantes no controle da hepatite c. Transaminase, also called aminotransferase, any of a group of enzymes that catalyze the transfer of the amino group. A transaminase is a type of enzyme whose activity is frequently measured, as part of a standard series of tests, to determine liver function.
Les asat etaient anciennement designees sous le sigle tgo ou sgot pour serumglutamyloxaloacetatetransferase. Annabelle, an 18yearold white woman, was referred by her primary care provider to our gastroenterology practice for markedly elevated serum transaminase levels. In medical practice, the most commonly determined are transaminases glutamyl oxalacetic tgo and glutamylopyruvic transaminase tgp. Atelier conduite a tenir devant une elevation chronique des. Alanine transaminase is one of the two transaminases measured aspartate transaminase is the other. Other transaminases also exist in mammalian organisms e. Biological effects of antiretroviral drugs in patients vih.
Nh 2 of an amino acid to a carbonyl compound, commonly an aketo acid an acid with the general formula rcocooh. If alanine or aspartate transaminases are more than three times the upper limits of normal in asymptomatic patients without any other liver abnormalities, the enzymes should be rechecked within a week and statins should be stopped temporarily if the enzymes are still elevated. Alanine aminotransferase alt is predominantly found in the liver, and most elevations are due to intrahepatic disease. The oxaloacetic and pyruvic glutamic transaminases tgo tgp were determined according to the kinetic method while urea and creatinine 14 were determined by the colorimetric method. Biological effects of antiretroviral drugs in patients vih positive of the national centre of blood donors in abidjan cote. Although less specific to the liver, the ast level is also elevated in. Lelevation chronique des transaminases est une situation frequente. Baixe no formato doc, pdf, txt ou leia online no scribd. Tgo y tgp son enzimas transaminasas o aminotransferasas. Transaminases definition of transaminases by medical.
The liver, for example, contains specific transaminases for the transfer of an amino group from glutamic acid to aketo acids that correspond to most of the other. An increase in their serum concentration is premature, occurs in the context of hepatocyte necrosis and their values become positive before. Ms clinicians monitor transaminase enzymes because they are good markers of the inflammation that may impair liver function. Transaminases in french, translation, englishfrench. Since, several hcv reports have described normal transaminase levels in about 25%30% of chronic hcv patients, there may be a potential advantage in assessing serum direct fibrosis markers that do not involve transaminases 27, of which itih4 can be considered as one. Transaminases alt e ast ou tgp e tgo trabalhosfeitos. There are a number of different types of transaminases, but the two commonly measured medically are alanine transaminase alt and aspartate transaminase ast. An increase in their serum concentration is premature, occurs in the context of hepatocyte necrosis and their values become positive before other tests reflecting the liver function. If ggf or ggp is really ggt, it would be gamma glutamyl transferase, which is refered to as ggt. Tgp, serum glutamopyruvate transferase, alat, alanineaminotransferase tgo, serum glutamooxaloacetate transferase asat, aspartateaminotransferase leur augmentation temoigne dune lesion cellulaire dans le foie, le coeur, les muscles ou les reins. Transaminase definition of transaminase by medical. Some of these cookies are essential to the operation of the site, while others help to improve your experience by providing insights into how the site is being used.180 1344 1468 794 1210 1244 363 1455 196 1196 1480 1516 1026 898 1486 2 17 919 238 528 1443 1267 682 758 856 1100 1005 438 266 965 1115 1497 507 1028 751 427 234 335 297 666 689 206 14 425 601 547